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River Publishers Series in Biomedical Engineering 

Algorithms for Sample Preparation with Microfluidic Lab-on-Chip

Sukanta Bhattacharjee, Indian Statistical Institute, India
Bhargab B. Bhattacharya, Indian Statistical Institute, India
Krishnendu Chakrabarty, Duke University, USA

ISBN: 9788770220552
e-ISBN: 9788770220545

Price: € 95.00

Available: February 2019

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Recent microfluidic technologies have brought a complete paradigm shift in automating biochemical processing on a tiny lab-on-chip (a.k.a. biochip) that replaces expensive and bulky instruments traditionally used in implementing bench-top laboratory protocols. Biochips have already made a profound impact on various application domains such as clinical diagnostics, DNA analysis, genetic engineering, and drug discovery, among others. They are capable of precisely manipulating micro-/pico-liter quantities of fluids, and provide integrated support for mixing, storage, transportation, and sensing, on-chip. In almost all bioprotocols, sample preparation plays an important role, which includes dilution and mixing of several fluids satisfying certain volumetric ratios. However, designing algorithms that minimize reactant-cost and sample-preparation time suited for microfluidic chips poses a great challenge from the perspective of protocol mapping, scheduling, and physical design.

Algorithms for Sample Preparation with Microfluidic Lab-on-Chip attempts to bridge the widening gap between biologists and engineers by introducing, from the fundamentals, several state-of-the-art computer-aided-design (CAD) algorithms for sample preparation with digital and flow-based microfluidic biochips.

Technical topics discussed in the book include:

  • Basics of digital and flow-based microfluidic lab-on-chip
  • Comprehensive review of state-of-the-art sample preparation algorithms
  • Sample-preparation algorithms for digital microfluidic lab-on-chip
  • Sample-preparation algorithms for flow-based microfluidic lab-on-chip


Algorithmic Microfluidics, Lab-on-Chip, Sample Preparation, Satisfiability