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International Journal of Translational ScienceJournal discontinued 2017


Pranela Rameshwar, Rutgers University, USA
Nicholas M. Ponzio, Rutgers University, USA

ISSN: 2246-8765 (Online Version)
Vol: 2016   Issue: 1

Published In:   January 2016

Publication Frequency: Continuous Article Publication

Search Available Volume and Issue for International Journal of Translational ScienceJournal discontinued 2017

Marie Sondey,
Novartis Institute of Biomedical Research, USA

I began my scientific journey as an undergraduate at Richard Stockton University where I fell in love with the lab conducting several independent research projects while earning a B.S. in Biology. The experiences included gene cloning and expression to induce spawning for aquaculture purposes and an exciting opportunity to work at the NJ-NSCORT (New Jersey NASA Specialized Center of Research and Technology) working on the development of a version of the Rutgers tomato with reduced biomass (waste) and increased fruit production for use in space.

My first full time opportunity after college was at Roche Diagnostics expanded upon past experiences with a shifted focus towards human health in the form of producing amplified material for use in PCR ELISA assays.

I continued my educational focus in Biotechnology at William Paterson University where I obtained my Master's Degree while concurrently discovering my fascination for Neuroscience and Biochemistry at the University of Medicine and Dentistry of New Jersey. I had the opportunity to study the production of neutralizing antibodies in Multiple Sclerosis patients, infection and neuroinvasion via the blood brain barrier of Lyme & Relapsing Fever spirochetal bacteria, as well as the influence of Tat mutations in high titer HIV patients.

I broadened my experience by pursuing the characterization of antibodies at the Biotech company Elusys, and continued to grow and combine past experiences at Schering-Plough Research Institute in Discovery efforts for an anti-amyloid antibody program. With the Merck merger I began diving into the world of Immunohistochemistry and Image Analysis among other things for a greater understanding of the mechanism and effectiveness of the small molecule inhibitor BACE on Alzheimer's Disease. This work lead to a poster at Cold Spring Harbor featuring the prevention and reduction of amyloid plaques in chronic mouse model studies by quantitative Biochemical and Immunohistochemical endpoints.

I am currently fascinated by the potential of utilizing stem cell models and developing new technologies for Neuroscience Drug Discovery at Novartis Institutes for Biomedical Research. The research integrates iPS cells with CRISPR engineering help identify drug targets and treatments.

River Publishers: International Journal of Translational Science<sup><font color=#f91b02>Journal discontinued 2017</font></sup>