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International Journal of Translational ScienceJournal discontinued 2017


Pranela Rameshwar, Rutgers University, USA
Nicholas M. Ponzio, Rutgers University, USA

ISSN: 2246-8765 (Print Version),

ISSN: 2246-8765 (Online Version)
Vol: 2016   Issue: 1

Published In:   January 2016

Publication Frequency: Continuous Article Publication

Search Available Volume and Issue for International Journal of Translational ScienceJournal discontinued 2017

Harikrishna Nakshatri, BVSc(DVM), PhD.,
Indiana University School of Medicine, USA

Harikrishna Nakshatri, BVSc(DVM), PhD., is the Marian J. Morrison Professor of Breast Cancer Research and Associate Director of IUSCC, Co-Program Leader of the Breast Cancer Program of IUSCC, Indiana University School of Medicine USA.

Dr. Nakshatri did his PhD in Memorial University, New Foundland, St. Johns, Canada, and post-doctoral fellowship in University Louis Pasteur, Strasbourg, France.

Dr. Nakshatri's research interests are on the mechanisms of anti-estrogen resistance and metastasis in breast cancer. Ongoing research in his lab includes elucidating the mechanisms by which the serine/threonine kinase AKT alters estrogen signaling and confers anti-estrogen resistance. His laboratory has identified and commercialized biomarkers that may predict response to anti-estrogen therapy. His laboratory was the first to demonstrate constitutive activation of NF-kappaB in a subset of breast cancer. Activated NF-kappaB confers chemotherapy resistance and enhances metastasis. An inhibitor of NF-kappaB developed by his lab in collaboration with other institutions is currently in phase I clinical trial for cancer. His laboratory is also investigating the mechanisms of organ-specific metastasis and the role of cancer stem cells in chemoresistance and metastasis. Understanding heterogeneity in the normal breast and microRNA-mediated systemic effects of cancer are his latest research interests.

National Institutes of Health (NIH), Department of Defense, American Cancer Society, Susan G. Komen for Cure, US Veterans Administration and other private foundations have funded his research. He has authored over 100 publications with citations exceeding 10,000. He has served/serving in scientific review committees of NIH, Department of Defense, Italian Association for Cancer Research, and Susan G. Komen for Cure. He is currently a member of the NIH Cancer Molecular Pathobiology Study Section (2012-2018) of NIH. He is also in the editorial boards of scientific journals and an Associate Editor of Cancer Research. Based on his scientific contribution to breast cancer, he is one among the 62 scientists selected from seven countries to serve in the inaugural Susan G. Komen for the Cure Scientific Advisory Council (renamed as Komen Scholars). He has trained over 16 post-doctoral fellows, surgical residents, and medical students.

River Publishers: International Journal of Translational Science<sup><font color=#f91b02>Journal discontinued 2017</font></sup>