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River Publishers Series in Biotechnology and Medical Research 

The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis

Cristian Pablo Pennisi, Aalborg University, Denmark
Mayuri Sinha Prasad, Indiana University-Purdue University Indianapolis, USA
Pranela Rameshwar, Rutgers University, USA

ISBN: 9788793379930

e-ISBN: 9788793519008

doi: https://doi.org/10.13052/rp-9788793519008

Price: €0.00

Available: December 2016

Print book available at List Price

[17.41 MB] Downloads: [778] Reads [589]    


How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation.

This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:

  • Stem cell biology
  • Cancer stem cells
  • Stem cell interactions with biomaterials
  • Engineering the stem cell microenvironment
  • Stem cells in tissue regeneration and repair

The Disputationes Workshop series is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. This book emerges as a result of the scientific contributions presented and discussed during the fifth Disputationes Workshop held in Aalborg (Denmark) in April 2014. The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences



Mesenchymal stem cells, pluripotent stem cells, cancer stem cells, cardiovascular disease, corneal regeneration, skeletal muscle, smooth muscle, breast cancer, glioblastoma, invasion, pathotropism, heterogeneity, bioactive surfaces, microtopography, mechanical cues, extracellular matrix, hypoxia, hydrogels, nanoparticles

Book Contents:

Chapter 1
Selective Expansion of Limbal Epithelial Stem Cells in Culture Using Hypoxia
by Chris Bath, Sufang Yang, Danson Muttuvelu, Trine Fink, Jeppe Emmersen, Henrik Vorum, Jesper Hjortdal and Vladimir Zachar
Download as a PDF [951KB]

Chapter 2
Mesenchymal Stem Cells and Pathotropism: Regenerative Potential and Safety Concerns
by Garima Sinha, Sarah A. Bliss, Lauren S. Sherman, Oleta A. Sandiford, Vipul Nagula and Pranela Rameshwar
Download as a PDF [571KB]

Chapter 3
Prospective Technologies for Cardiac Repair
by Francesca Pagliari, Luciana Carosella and Paolo Di Nardo
Download as a PDF [1652KB]

Chapter 4
Does Inter-Individual Heterogeneity in the Normal Breast Corrupt Cancer Stem Cell and/or Cancer-Specific Signaling Characterization?
by Harikrishna Nakshatri
Download as a PDF [60KB]

Chapter 5
The Role of Physical Microenvironmental Cues on Myogenesis: Implications for Tissue Engineering of Skeletal Muscle
by Cristian Pablo Pennisi, Stavros Papaioannou, John Rasmussen and Vladimir Zachar
Download as a PDF [1263KB]

Chapter 6
Effect of Bioactive Growth Surfaces on Human Mesenchymal Stem Cells: A Pilot Biomarker Study to Assess Growth and Differentiation
by Liliana Craciun, Pranela Rameshwar, Steven J. Greco, Ted Deisenroth and Carmen Hendricks-Guy
Download as a PDF [5370KB]

Chapter 7
Embryonic Stem Cell Markers in Cancer: Cripto-1 Expression in Glioblastoma
by Meg Duroux, Linda Pilgaard and Pia Olsen
Download as a PDF [475KB]

Chapter 8
Artificial Corneas, and Reinforced Composite Implants for High Risk Donor Cornea Transplantation
by May Griffith, Chyan-Jang Lee and Oleksiy Buznyk
Download as a PDF [2630KB]

Chapter 9
Molecular Mechanisms of Smooth Muscle Cell Differentiation from Adipose-Derived Stem Cell
by FangWang and Jeppe Emmersen
Download as a PDF [323KB]


The Stem Cell Microenvironment and its Role in Regenerative Medicine and Cancer Pathogenesis