Description:
How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation.
Stem cell biology
Cancer stem cells
Stem cell interactions with biomaterials
Engineering the stem cell microenvironment
Stem cells in tissue regeneration and repair The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences
Keywords:
Mesenchymal stem cells, pluripotent stem cells, cancer stem cells, cardiovascular disease, corneal regeneration, skeletal muscle, smooth muscle, breast cancer, glioblastoma, invasion, pathotropism, heterogeneity, bioactive surfaces, microtopography, mechanical cues, extracellular matrix, hypoxia, hydrogels, nanoparticles
Book Contents:
Chapter 1 Selective Expansion of Limbal Epithelial Stem Cells in Culture Using Hypoxia by Chris Bath, Sufang Yang, Danson Muttuvelu,
Trine Fink, Jeppe Emmersen, Henrik Vorum,
Jesper Hjortdal and Vladimir Zachar Download as a PDF [951KB]
Chapter 2 Mesenchymal Stem Cells and Pathotropism: Regenerative Potential and Safety Concerns by Garima Sinha, Sarah A. Bliss, Lauren S. Sherman, Oleta A. Sandiford,
Vipul Nagula and Pranela Rameshwar Download as a PDF [571KB]
Chapter 3 Prospective Technologies for Cardiac Repair by Francesca Pagliari, Luciana Carosella and Paolo Di Nardo Download as a PDF [1652KB]
Chapter 4 Does Inter-Individual Heterogeneity in the Normal Breast Corrupt Cancer Stem Cell and/or Cancer-Specific Signaling Characterization? by Harikrishna Nakshatri Download as a PDF [60KB]
Chapter 5 The Role of Physical Microenvironmental Cues on Myogenesis: Implications for Tissue Engineering of Skeletal Muscle by Cristian Pablo Pennisi, Stavros Papaioannou, John Rasmussen
and Vladimir Zachar Download as a PDF [1263KB]
Chapter 6 Effect of Bioactive Growth Surfaces on Human Mesenchymal Stem Cells: A Pilot Biomarker Study to Assess Growth and Differentiation by Liliana Craciun, Pranela Rameshwar, Steven J. Greco,
Ted Deisenroth and Carmen Hendricks-Guy Download as a PDF [5370KB]
Chapter 7 Embryonic Stem Cell Markers in Cancer: Cripto-1 Expression in Glioblastoma by Meg Duroux, Linda Pilgaard and Pia Olsen Download as a PDF [475KB]
Chapter 8 Artificial Corneas, and Reinforced Composite Implants for High Risk Donor Cornea Transplantation by May Griffith, Chyan-Jang Lee and Oleksiy Buznyk Download as a PDF [2630KB]
Chapter 9 Molecular Mechanisms of Smooth Muscle Cell Differentiation from Adipose-Derived Stem Cell by FangWang and Jeppe Emmersen Download as a PDF [323KB]
