Direct Nerve Stimulation for Induction of Sensation and Treatment of Phantom Limb Pain

Direct Nerve Stimulation for Induction of Sensation and Treatment of Phantom Limb Pain

River Publishers Series in Biomedical Engineering

Direct Nerve Stimulation for Induction of Sensation and Treatment of Phantom Limb Pain

Editor: Winnie Jensen, Aalborg University, Denmark

ISBN: 9788770220767

Available: December 2019


The amputation of a limb is a surgical intervention used as a last resort to remove irreparably damaged, diseased, or congenitally malformed limbs where retention of the limb is a threat to the well-being of the individual. The procedure traumatically alters the body image, but often leaves sensations that refer to the missing body part, the phantom limb. In 50-80% of cases, these sensations are perceived as painful and referred to as 'Phantom Limb Pain'.

Direct Nerve Stimulation for Induction of Sensation and Treatment of Phantom Limb Pain provides an overview of research, experiences and results for the design, development and test of hardware and software components, and the ambition to safely implant and evaluate a novel neural interface system to combat phantom limb pain in an amputee volunteer subject.
Phantom limb pain treatment, implantable electrodes, sensory feedback, electrical stimulation, selectivity, biocompatibility, clinical test of novel implantable medical devices

Chapter 0: Preface


408

Chapter 1: Introduction
by Winnie Jensen


500

Chapter 2: An Introduction to Phantom Limb Pain
by Caleb C. Comoglio, Kristine Mosier and Ken Yoshida


450

Chapter 3: Neurobiology of Pain
by Víctor M. López-Álvarez, Elena Redondo-Castro and Xavier Navarro


434

Chapter 4: The TIME Implantable Nerve Electrode
by Tim Boretius and Thomas Stieglitz


453

Chapter 5: Modeling to Guide Implantable Electrode Design
by Giacomo Valle and Silvestro Micera


388

Chapter 6: Biocompatibility of the TIME Implantable Nerve Electrode
by Jordi Badia, Aritra Kundu, Kristian R. Harreby, Tim Boretius, Thomas Stieglitz, Winnie Jensen and Xavier Navarro


383

Chapter 7: Selectivity of the TIME Implantable Nerve Electrode
by Jordi Badia1, Kristian R. Harreby, Aritra Kundu, Tim Boretius, Thomas Stieglitz, Winnie Jensen and Xavier Navarro


410

Chapter 8: Synchronous Multichannel Stimulator with Embedded Safety Procedure to Perform 12-Poles TIME-3H 3D Stimulation
by David Andreu, Pawel Maciejasz, Robin Passama, Guy Cathebras, Guillaume Souquet, LoicWauters, Jean-Louis Divoux, and David Guiraud


354

Chapter 9: Computerized "Psychophysical Testing Platform" to Control and Evaluate Multichannel Electrical Stimulation-Based Sensory Feedback
by Bo Geng, Ken Yoshida, David Guiraud, David Andreu, Jean-Louis Divoux and Winnie Jensen


359

Chapter 10: A New Treatment for Phantom Limb Pain Based on Restoration of Somatosensory Feedback Through Intraneural Electrical Stimulation
by Guiseppe Granata, Winnie Jensen, Jean-Louis Divoux, David Guiraud, Silvestro Micera, Xavier Navarro, Thomas Stieglitz, Ken Yoshida and P. M. Rossini


379

Chapter 11: Future Applications of the TIME
by Thomas Stieglitz


378